MessageSendError: Error: couldn't send email: mailhost [Errno 111] Connection refused

Hi all,

When I access
http://localhost:8080/issues/ in a browser

after I run the following command:
[huskier@SL6xServer bak]$ roundup-server
issues=/opt/roundup/trackers/issues/
Roundup server started on localhost:8080

I've got the following error:
Thu Oct 31 08:31:06 2013: An error occurred. Please check the server log
for more infomation.
in the browser, and got the following error in the command terminal.
MessageSendError: Error: couldn't send email: mailhost [Errno 111]
Connection refused.

I've configured the DNS and SMTP, and I could send mails to my GMail
account from command line. The domain name is server.siom.org, and the host
name is the same.

My OS is Scientific Linux 6.x (similiar to CentOS 6.x), and roundup and
python version is as following:
[root@server issues]# roundup-admin -v
1.4.20 (python 2.6.6)

Any ideas?

Thanks.

Huskier

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