Client authentication error -- suddenly

Howdy, folks,

I'm running MySQL 4.1.7 on a Red Hat 9 box, and this morning,
abruptly, I started receiving this error (specifics replaced for
security purposes):

DBI connect('DATABASE:IP','USER',...) failed: Client does not support
authentication protocol requested by server; consider upgrading MySQL
client at [script path]

I had 2.9003 installed and installed 2.9005_3 in case that was the
problem. I had DBI 1.40 installed and upgraded to 1.45, as well. I
cannot seem to get this to work.

I checked the MySQL documentation and tried to switch to "old
passwords" to see if that helped. No luck.

I can't figure out why this suddenly happened at 6 am with me being
the only person with access to the databases and the Web server, and
not making any changes.

I had just stopped a large MySQL select operation that had been
running for 12 hours. But it was running on another instance of MySQL
-- I have two instances at different ports with different paths
running.

Any help is very very welcome, as my system is currently down.

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