RE: Indiana Sales and Use Tax

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you are only to charge sales tax to customers receiving delivery of your product in the state your business is registered in.
ie: you sell to me in california .. no tax
your neighbor in Indiana buys from your store .. they pay the Indiana state sales tax rate.
osC will do this automatically once you set up the tax rate/zone for Indiana.. 
It will only charge tax to customers registered with an Indiana address.
I hope that answers your question ;)