closed connection during Zope2 request

Hi.

We keep running into errors like "ZODB.Connection Shouldn't load state 
for ...", but they don't seem to be due to the usual persistent objects 
cached in ramcache
or similar, because we have those errors in several different situations 
and on different installations with different custom packages.

By analyzing on depth we noticed a weird behavior. It looks like the 
connection is somehow closed in the middle of a request. We tried to get 
more info saving the stack in the _debug_info of the connection with 
traceback.format_stack() everytime the connection close happens, in 
order to eventually print it in case of exception like "ZODB.Connection 
Shouldn't load state for ..."

Below you can find some lines of the stack traces that we get when we 
run into the errors.
What looks weird to us is that apparently it suddenly calls the __del__ 
of a ZApplication.Cleanup instance that's on hold on the request, 
therefore closing the ZODB connection.

Any ideas about why this is happening or about what else we can 
investigate on?

Thanks in advance

Mauro.

...
File 
"/opt/cache/buildout/eggs/zope.tal-3.5.2-py2.7.egg/zope/tal/talinterpreter.py", 
line 182, in __init__
     self.program = program
File 
"/opt/cache/buildout/eggs/Zope2-2.13.23-py2.7.egg/App/ZApplication.py", 
line 84, in __del__
     self._jar.close()
File 
"/opt/cache/buildout/eggs/ZODB3-3.10.5-py2.7-linux-x86_64.egg/ZODB/Connection.py", 
line 384, in close
     self.setDebugInfo("%s" % traceback.format_stack())

----------------------------

...
File 
"/opt/cache/buildout/eggs/Products.PlonePAS-5.0.9-py2.7.egg/Products/PlonePAS/plugins/ufactory.py", 
line 72, in _getPAS
     return self.acl_users
File 
"/opt/cache/buildout/eggs/Zope2-2.13.23-py2.7.egg/App/ZApplication.py", 
line 84, in __del__
     self._jar.close()
File 
"/opt/cache/buildout/eggs/ZODB3-3.10.5-py2.7-linux-x86_64.egg/ZODB/Connection.py", 
line 384, in close
     self.setDebugInfo("%s" % traceback.format_stack())

----------------------------

...
File 
"/opt/cache/buildout/eggs/Zope2-2.13.23-py2.7.egg/Products/PageTemplates/Expressions.py", 
line 88, in trustedBoboAwareZopeTraverse
     path_items = list(path_items)
File 
"/opt/cache/buildout/eggs/Zope2-2.13.23-py2.7.egg/App/ZApplication.py", 
line 84, in __del__
     self._jar.close()
File 
"/opt/cache/buildout/eggs/ZODB3-3.10.5-py2.7-linux-x86_64.egg/ZODB/Connection.py", 
line 384, in close

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