Always wait for ctrl, alt ... to be up before executing command?

"hypersam.tw-/[email protected] [power-pro]" <[email protected]>
Newsgroups gmane.comp.windows.power-pro
Message-ID <[email protected]>
May I ask should I check it or uncheck it. What is the reason?
 

 I use hotkeys to switch between programs. Waiting for the modifier up is a little clumsy. But I'm not sure about the side effects if uncheck it.
 

 Your thoughts are needed.
 

 Thanks.
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