CryoNet #31821 - #31822

CryoNet - Thu 23 Jul 2009

    #31821: Larry King [Kennita Watson]
    #31822: anti ischemia drug [Leo]

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Message #31821
From: Kennita Watson <[email protected]>
Subject: Larry King
Date: Wed, 22 Jul 2009 02:25:07 -0700

Found this online:  "Come join the discussion on Larry's blog! Check  
out http://larrykinglive.blogs.cnn.com/ and become a part of Larry  
King Live! You can chat, ask questions, interact with guests,  
producers, even Larry! And who knows, your thoughts might even end up  
in the broadcast!"

Someone ambitious might ask him about his comments on Conan O'Brien --  
maybe even read his book (Larry King:  My Remarkable Journey), which  
might say more.  Anybody wanna buy it for me for my birthday (7/28)? :-)

Live long and prosper,
Kennita

Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=31821

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Message #31822
From: "Leo" <[email protected]>
Subject: anti ischemia drug
Date: Wed, 22 Jul 2009 21:25:52 +0200

New anti-ischemia drug useble for cryo patients?.
maybe its useble before its aproved by the FDA.

http://www.cbiolabs.com/applications_04.php



Acute Organ Failure

CBLI's finding that Protectans are able to prevent death of normal cells in the face of stresses that normally induce apoptosis suggests a wide range of potential applications for these compounds. In addition to radiation exposure, another type of stress that leads to tissue damage through apoptosis of normal, non-cancerous cells is the ischemia (limited blood flow leading to local hypoxia) that occurs during acute medical conditions such as stroke, heart attack and renal failure.

CBLI researchers in collaboration with investigators from the Cleveland Clinic have demonstrated that injection of Protectan CBLB502, an optimized derivative of bacterial flagellin, effectively prevents acute renal failure and subsequent death in a mouse model of ischemia-reperfusion renal injury. Thus, CBLI expects that this class of drugs will be useful in limiting the tissue damage associated with a number of different acute organ failure scenarios. Pre-clinical studies aimed at validating this hypothesis are ongoing. The anti-ischemia effect of CBLB502 also has a potentially important defense application. The compound is being tested for its ability to reduce tissue damage associated with the use of tourniquets to prevent excessive bleeding from wounded limbs. If effective in this scen
 ario, CBLB502 could allow significantly broader use of tourniquets, which has been limited by the high risk of limb loss due to prolonged tissue hypoxia. Systemic and local effects of tourniquet use are described in

 http://www.jbjs.org.uk/cgi/reprint/62-B/3/385.pdf.





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