CryoNet #33311 - #33313

CryoNet - Sat 5 Feb 2011

    #33311: Re: CryoNet #33309 - #33310 [David Stodolsky]
    #33312: Re: LongeCity/ImmInst  Anti-Aging Research [benbest]
    #33313: anti-aging effects of raspberry ketone [oberon]

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Message #33311
Subject: Re: CryoNet #33309 - #33310
From: David Stodolsky <[email protected]>
Date: Fri, 4 Feb 2011 12:27:52 +0100
References: <[email protected]>

On 4 Feb 2011, at 11:00 AM, CryoNet wrote:

> To these excellent comments I would add that there is a brain drain from 
> professions that may create wealth to those mentioned that destroy it.

The real brain drain, from the life-extension point of view, is the diversion of scientific manpower from life promotion to life destruction. Military expenditures result in the diversion on manpower and the industrialization of death. It also results in wealth destruction, but that is merely an intermediate factor. 


> 
> People can make far more money in these professions than they can working in 
> wealth creating industries, unless they are actually the owners or managers 
> of these industries. The best example of the latter is Bill Gates, of 
> course, whose wealth far exceeds the wildest dreams of the most avaricious 
> of the non-productive professionals. But these super sucessful people are 
> extremely rare indeed. By and large, the non-productive professional earns 
> more than the productive one. In addition, the affluence of these 
> non-productive professionals encourages inefficient working practises, 
> making their clients pay even more for the services provided.
> 
> Over the past half century, the best way to make money was to discover how 
> to borrow it, and use the money you have borrowed to buy things whose 
> apparent cost is rising faster than your accumulating pile of debt and 
> interest. At some point you have to sell part of your portfolio to pay off 
> your debt, and you have got something for nothing. The losers are the savers 
> on fixed interest who were getting a below inflation return after tax, ie a 
> negative returen on their savings.

This analysis assumes that 'free enterprise' is an adequate description of what has happened in the last half century. However, the World economy is dominated by monopoly capital, which collects 'rents' from its control of 'markets'. All of the leading international flows - oil, weapons, drugs - are monopoly controlled. Bill Gates owes his fortune to the abuse of MS's operating system monopoly, as proven in numerous court findings.


dss

David Stodolsky
[email protected]  Skype: davidstodolsky

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Message #33312
Date: Fri, 04 Feb 2011 10:27:16 -0500
From: [email protected]
Subject: Re: LongeCity/ImmInst  Anti-Aging Research

   Shannon Vyff wrote:

http://www.cryonet.org/cgi-bin/dsp.cgi?msg=33310

> The link below is to a fund raising effort
> by the LongeCity/ImmInst  for a
> research project our advisor Aubrey de Grey
> and other advisers felt has a lot of potential
> and is worthy of our efforts to fund it-but
> we need your help and have approved a
> matching grant, dollar for dollar anything
> you donate will be doubled (tax deductible
> in the US):
>
> http://www.imminst. org/Research2010 B

That link should have been

http://www.imminst.org/Research2010B

As Shannon mentioned,

The link states: "Any donation, of any amount is
appreciated. We need at least $16.000 to get going,
with the matched funding in place that means at
least $8000 from donors like you. Any surplus
would go into the next scientific research
initiative that is already in the pipeline."

I am told that the next scientific initiative
that is in the pipeline will be a project for
Aschwin and Chana de Wolf to study reperfusion
injury that I wrote. It has been known for a
long time that after a certain period of time
reperfusion is harmful rather than beneficial,
but it is not known how long that time is. For
cryonics purposes it would be good to know how
long after circulation stops it is beneficial
rather than harmful to do a blood washout. The
effect of temperature would be investigated,
and hopefully the experimental results could
be published in a peer-reviewed journal.

  I hope that the life-extension community
(including the cryonics community) can finish
funding the brain microglia regeneration/rejuvenation
project and follow this with successful funding
of the cryonics reperfusion injury project.

      -- Ben Best

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Message #33313
Date: Fri, 4 Feb 2011 13:47:34 -0800 (PST)
From: [email protected]
Subject: anti-aging effects of raspberry ketone

Raspberry ketone grows hair, rejuvenates skin elasticity, and even reduces body fat.
A rodent longevity trial might show some interesting effects.

Growth Horm IGF Res. 2008 Aug;18(4):335-44. Epub 2008 Mar 5.
Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans.
Harada N, Okajima K, Narimatsu N, Kurihara H, Nakagata N. Department of Translational Medical Science Research, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
Abstract
  Sensory neurons release calcitonin gene-related peptide (CGRP) on activation. We recently reported that topical application of capsaicin increases facial skin elasticity and promotes hair growth by increasing dermal insulin-like growth factor-I (IGF-I) production through activation of sensory neurons in mice and humans. Raspberry ketone (RK), a major aromatic compound contained in red raspberries (Rubus idaeus), has a structure similar to that of capsaicin. Thus, it is possible that RK activates sensory neurons, thereby increasing skin elasticity and promoting hair growth by increasing dermal IGF-I production. In the present study, we examined this possibility in mice and humans. RK, at concentrations higher than 1 microM, significantly increased CGRP release from dorsal root ganglion ne
 urons (DRG) isolated from wild-type (WT) mice and this increase was completely reversed by capsazepine, an inhibitor of vanilloid receptor-1 activation. Topical application of 0.01% RK incre
 ased dermal IGF-I levels at 30 min after application in WT mice, but not in CGRP-knockout mice. Topical application of 0.01% RK increased immunohistochemical expression of IGF-I at dermal papillae in hair follicles and promoted hair re-growth in WT mice at 4 weeks after the application. When applied topically to the scalp and facial skin, 0.01% RK promoted hair growth in 50.0% of humans with alopecia (n=10) at 5 months after application and increased cheek skin elasticity at 2 weeks after application in 5 females (p<0.04). These observations strongly suggest that RK might increase dermal IGF-I production through sensory neuron activation, thereby promoting hair growth and increasing skin elasticity.
PMID: 18321745

Planta Med. 2010 Oct;76(15):1654-8. Epub 2010 Apr 27.
Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes.
Park KS. Nutrition & Functional Food Research Team, Korea Food & Drug Administration, Seoul, Korea.
Abstract
  Raspberry ketone (RK) is a natural phenolic compound of the red raspberry. The dietary administration of RK to male mice has been reported to prevent high-fat diet-induced elevation in body weight and to increase lipolysis in white adipocytes. To elucidate a possible mechanism for the antiobesity action of RK, its effects on the expression and the secretion of adiponectin, lipolysis, and fatty acid oxidation in 3T3-L1 were investigated. Treatment with 10"AuM of RK increased lipolysis significantly in differentiated 3T3-L1 cells. An immunoassay showed that RK increased both the expression and the secretion of adiponectin, an adipocytokine mainly expressed and secreted by adipose tissue. In addition, treatment with 10"AuM of RK increased the fatty acid oxidation and suppressed lipid accumu
 lation in 3T3-L1 adipocytes. These findings suggest that RK holds great promise as an herbal medicine since its biological activities alter the lipid metabolism in 3T3-L1 adipocytes.
AC Georg Thieme Verlag KG Stuttgart * New York.
PMID: 20425690

Life Sci. 2005 May 27;77(2):194-204. Epub 2005 Feb 25.
Anti-obese action of raspberry ketone.
Morimoto C, Satoh Y, Hara M, Inoue S, Tsujita T, Okuda H. Department of Medical Biochemistry, Ehime University School of Medicine, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan.
Abstract
  Raspberry ketone (4-(4-hydroxyphenyl) butan-2-one; RK) is a major aromatic compound of red raspberry (Rubus idaeus). The structure of RK is similar to the structures of capsaicin and synephrine, compounds known to exert anti-obese actions and alter the lipid metabolism. The present study was performed to clarify whether RK helps prevent obesity and activate lipid metabolism in rodents. To test the effect on obesity, our group designed the following in vivo experiments: 1) mice were fed a high-fat diet including 0.5, 1, or 2% of RK for 10 weeks; 2) mice were given a high-fat diet for 6 weeks and subsequently fed the same high-fat diet containing 1% RK for the next 5 weeks. RK prevented the high-fat-diet-induced elevations in body weight and the weights of the liver and visceral adipose ti
 ssues (epididymal, retroperitoneal, and mesenteric). RK also decreased these weights and hepatic triacylglycerol content after they had been increased by a high-fat diet. RK significantly in
 creased norepinephrine-induced lipolysis associated with the translocation of hormone-sensitive lipase from the cytosol to lipid droplets in rat epididymal fat cells. In conclusion, RK prevents and improves obesity and fatty liver. These effects appear to stem from the action of RK in altering the lipid metabolism, or more specifically, in increasing norepinephrine-induced lipolysis in white adipocytes.
PMID: 15862604

Xenobiotica. 1982 Apr;12(4):249-57.
The metabolism of 4-(4-hydroxyphenyl)butan-2-one (raspberry ketone) in rats, guinea-pigs and rabbits.
SporstA,l S, Scheline RR.
Abstract
  1. The metabolism of 4-(4-hydroxyphenyl)butan-2-one(raspberry ketone) was studied in rats, guinea-pigs and rabbits. 2. Following intragastric dosage (1 mmol/kg) urinary metabolite excretion was nearly complete within 24 h, amounting to roughly 90% of the dose in all species. 3. The most prominent urinary metabolites were raspberry ketone and its corresponding carbinol, both largely conjugated with glucuronic acid and/or sulphate. The extent of ketone reduction was greatest in rabbits. 4. Oxidative metabolism included ring hydroxylation and side-chain oxidation. The latter pathway led to 1,2- and 2,3-diol derivatives. It is proposed that the latter undergo cleavage to furnish the C6-C3 and C6-C2 derivatives detected.
PMID: 7113261

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