WebSite Latency

I am having problems with severe latency on my website. I have one Sun Netra
with Apache. I have an average of 25-50 users connected simultaneously, with
each users having 3-2 browser sessions going. Our website contains 5 frames.
It gets to the point where the website completely locks  up. Here is the
message I get in the error_log:

My settings in the HTTPD.CONF file are:

MinSpareServers 60
MaxSpareServers 100
StartServers 60
MaxClients 384
MaxRequestsPerChild 10000

Is there any insight you can provide into this issue with the numbers I
included? Any help is greatly appreciated.