[wormhole] One Cannot Live By RNA Alone

EpSil0n-// <[email protected]> Tue, 12 Jan 2010 12:56:16 -0600 (CST)
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  Hank Roth, on the InterNUT since 1982
Past (post) Commander Jewish War Veterans
* Cryptologist and Voice Security in the White House
and in the War Room for JCS at the Pentagon
   BIO [with pics] http://inyourface.info/bio/

--------------------------------------------------
--------------------------------------------------

                            One Cannot Live by RNA Alone

     And just in case you think I am talking only about Homo sapiens, you
     are wrong. We are neither the end result of evolution nor the highest
     and best use of evolution, just another example of evolution - and one
     which is surely not long for this world. There is no reason why we
     should not follow the same fate as 99.9% of all the other species that
     once lived on the planet.

     "We are neither the fastest nor the strongest of creatures. We're not
     even the most prolific: in terms of biomass, ants are more plentiful,
     and they've been around much longer..." (Frank T. Vertosick, Jr., The
     Genus Within - 2002)

     Science and the natural law of science rules life and everything in the
     universe. Although it is also quite possible that natural law may be
     different elsewhere in the universe and different galaxies and
     multiverses may have varying natural laws different than our own.

     Just as the extreme right wing has been anti-science, for far too long
     an extremist "radical" political left has resisted science preferring a
     more idealized romantic world view where everyone has a greater
     potential for doing good. That may be the ideal view but it is not the
     right view.

     "So the tendency toward slaughter that manifested itself in the Chinese
     Cultural Revolution is not the product of agriculture, technology,
     television, or materialism. It is not an invention of either Western or
     Eastern civilization. It is not a uniquely human proclivity at all. It
     comes from something both sub- and super- human, something we share
     with apes, fish, and ants--a brutality that speaks to us through the
     animals in our brain. If man has contributed anything of his own to the
     equation, it is this: He has learned to dream of peace. But to achieve
     that dream, he will have to overcome what nature has built into him."
     (Howard Bloom, The Lucifer Principle - 1995)

     Life is basically a simple idea but complex enough to add wonderment
     and awe to it. We can't help but be humble in the presence of nature's
     wonderment and great majesty.

     AT first RNA did rule our world. BUT there were complications. There
     there was DNA. DNA replicates but cannot do so unassisted. Replication
     needs proteins which are large molecules chemically different from DNA.
     And proteins, like DNA are built of subunits of amino acids in a long
     chain. It is the business of each cell to put to work 20 of these amino
     acids, which are called building blocks, to form the proteins.

     So where did these amino acids come from? What is the origin of amino
     acids? See "The Origin of Life on the Earth," by L. E. Orgel;
     Scientific American, October 1994., the Stanley Miller experiment first
     published in 1953 where he applied a spark to a mix of gases resembling
     early conditions on Earth out of which two amino acids of the 20 were
     formed. Also see info re: Murchison meteorite, which impacted with
     Earth in 1969, in which 80 amino acids were found, out of which were
     ample building blocks, i.e. nucleotides, for the formation of life. "By
     extrapolation of these results, some writers have presumed that all of
     life's building could be formed with ease in Miller-type experiments
     and were present in meteorites and other extraterrestrial bodies. This
     is not the case." (Source: Scientific American)

     Amino acids make proteins. These proteins do a variety of tasks, they
     are the _handymen_ of living cells. But it doesn't end there. The
     handymen; that is, the proteins need enzymes, which are _expeditors_
     which hasten chemical processes, making them useful for life.

     It is the DNA which contains the recipe for the construction of the
     protein which cannot be copied or retrieved.

     Enter RNA, a class of molecule, like the DNA which is assembled in a
     helix of nucleotide (protein) building blocks. RNA resembles DNA but it
     is the molecule which edits and censors DNA code (instructions).

DNA and RNA are in a matter of speaking cousins.

     There are clues that RNA appeared before proteins and DNA in the
     evolution of life. There are small molecules, called _cofactors_ which
     perform enzyme-catalyzed reactions and they carry an attached
     nucleotide with no known function, so some scientists have speculated
     that they are _molecular fossils_ - that is, they are relics descended
     when RNA alone, without DNA ruled the natural biochemical world. We
     don't really know for sure, therefore it is just a hypothesis (though
     it is a good one) that life began with RNA alone.

     And what happened before RNA? There are still many questions we cannot
     answer and until there are answers to these and other questions much of
     it will be attributed to an intelligent designer because being
     inexplicable the natural course for those who do not have an answer is
     to invent one and attribute all things inexplicable to the
     super-inventor of everything, to that mysterious supernatural thing
     referred to as GOD. That isn't really an answer for anything but it is
     the meme most humans adopt as reasonable. And it is difficult to
     impossible to debate the existence of god, no matter how unreasonable
     the belief in a belief is - with those committed to that belief. How
     did that first self-replicating RNA arise? What made RNA? Are Did RNA
     just emerge out of gray-green goo?

     There are opposing views (Miller experiment) and what has been found in
     meteors is sufficient to produce the basic Watson-Crick building blocks
     necessary for life.

     The Scientific American reported that analysis of "several meteorites
     led the scientists who conducted the work to a different conclusion:
     inanimate nature has a bias toward the formation of molecules made of
     fewer rather than greater numbers of carbon atoms, and thus shows no
     partiality in favor of creating the building blocks of our kind of
     life. (When larger carbon-containing molecules are produced, they tend
     to be insoluble, hydrogen-poor substances that organic chemists call
     tars.) I have observed a similar pattern in the results of many spark
     discharge experiments."

     "Amino acids, such as those produced or found in these experiments, are
     far less complex than nucleotides. Their defining features are an amino
     group (a nitrogen and two hydrogens) and a carboxylic acid group (a
     carbon, two oxygens and a hydrogen) both attached to the same carbon.
     The simplest of the 20 used to build natural proteins contains only two
     carbon atoms. Seventeen of the set contain six or fewer carbons. The
     amino acids and other substances that were prominent in the Miller
     experiment contained two and three carbon atoms. By contrast, no
     nucleotides of any kind have been reported as products of spark
     discharge experiments or in studies of meteorites, nor have the smaller
     units (nucleotides) that contain a sugar and base but lack the
     phosphate." (ibid)

     "To rescue the RNA-first concept from this otherwise lethal defect, its
     advocates have created a discipline called prebiotic synthesis. They
     have attempted to show that RNA and its components can be prepared in
     their laboratories in a sequence of carefully controlled reactions,
     normally carried out in water at temperatures observed on Earth. Such a
     sequence would start usually with compounds of carbon that had been
     produced in spark discharge experiments or found in meteorites. The
     observation of a specific organic chemical in any quantity (even as
     part of a complex mixture) in one of the above sources would justify
     its classification as "prebiotic," a substance that supposedly had been
     proved to be present on the early Earth. Once awarded this distinction,
     the chemical could then be used in pure form, in any quantity, in
     another prebiotic reaction. The products of such a reaction would also
     be considered "prebiotic" and employed in the next step in the
     sequence." (ibid)

     In any event the controversy is far from being resolved at this point
     in time and any further explanation of the RNA first argument is way
     above my pay grade but I wanted to at least lay out the essense of the
     conflict which persists for this conundrum.

     I think it is unfortunate that many of those who favor an Intelligent
     Design approach will use this as an example of the scientific inability
     to explain life.

     There have been numerous other theories proposed for RNA or RNA type
     substances playing a role in the origin of life on Earth. Most of these
     theories vis-a-vis prebiotic Earth also rely on hypothetical
     presumptions that Nucleotide Watson-Crick base pairs type replication
     was used in the formation of life in prebiotic Earth. It has not been
     possible to reproduce life using scientific experimentation; at least
     not so that cytosine can be created, one of the four molecules
     necessary for the Watson-Crick base for ATCG. Nor has Cytosine been
     found in any analysis of meteorites or products of spark discharge
     experimentation. It has been suggested that on the basis of evidence or
     the lack thereof, it is unlikely that cytosine played a role in the
     origin of life. However, theories that involve replicators that
     function without the Watson-Crick pairs, or no replicator at all also
     remain as viable alternatives.

      Hank Roth

     [user_nogender.gif] Related Content
     All quotes are Fair Use for educational purposes
     Title 17 U.S.C. Section 107, Copyright Law

     Permalink: http://inyourface.info/ArT/Sci/Nucleic.shtml
     Today is

                                 [viewed times]


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      <p><br>
  Hank Roth, on the InterNUT since 1982<br>
Past (post) Commander Jewish War Veterans<br>
* Cryptologist and Voice Security in the White House<br>
and in the War Room for JCS at the Pentagon<br>
   BIO [with pics] <a href="http://inyourface.info/bio/">http://inyourface.<wbr>info/bio/</a><br>
<br>
------------<wbr>---------<wbr>---------<wbr>---------<wbr>---------<wbr>--<br>
------------<wbr>---------<wbr>---------<wbr>---------<wbr>---------<wbr>--<br>
<br>
One Cannot Live by RNA Alone<br>
<br>
And just in case you think I am talking only about Homo sapiens, you<br>
     are wrong. We are neither the end result of evolution nor the highest<br>
     and best use of evolution, just another example of evolution - and one<br>
     which is surely not long for this world. There is no reason why we<br>
     should not follow the same fate as 99.9% of all the other species that<br>
     once lived on the planet.<br>
<br>
&quot;We are neither the fastest nor the strongest of creatures. We're not<br>
     even the most prolific: in terms of biomass, ants are more plentiful,<br>
     and they've been around much longer...&quot; (Frank T. Vertosick, Jr., The<br>
     Genus Within - 2002)<br>
<br>
Science and the natural law of science rules life and everything in the<br>
     universe. Although it is also quite possible that natural law may be<br>
     different elsewhere in the universe and different galaxies and<br>
     multiverses may have varying natural laws different than our own.<br>
<br>
Just as the extreme right wing has been anti-science, for far too long<br>
     an extremist &quot;radical&quot; political left has resisted science preferring a<br>
     more idealized romantic world view where everyone has a greater<br>
     potential for doing good. That may be the ideal view but it is not the<br>
     right view.<br>
<br>
&quot;So the tendency toward slaughter that manifested itself in the Chinese<br>
     Cultural Revolution is not the product of agriculture, technology,<br>
     television, or materialism. It is not an invention of either Western or<br>
     Eastern civilization. It is not a uniquely human proclivity at all. It<br>
     comes from something both sub- and super- human, something we share<br>
     with apes, fish, and ants--a brutality that speaks to us through the<br>
     animals in our brain. If man has contributed anything of his own to the<br>
     equation, it is this: He has learned to dream of peace. But to achieve<br>
     that dream, he will have to overcome what nature has built into him.&quot;<br>
     (Howard Bloom, The Lucifer Principle - 1995)<br>
<br>
Life is basically a simple idea but complex enough to add wonderment<br>
     and awe to it. We can't help but be humble in the presence of nature's<br>
     wonderment and great majesty.<br>
<br>
AT first RNA did rule our world. BUT there were complications. There<br>
     there was DNA. DNA replicates but cannot do so unassisted. Replication<br>
     needs proteins which are large molecules chemically different from DNA.<br>
     And proteins, like DNA are built of subunits of amino acids in a long<br>
     chain. It is the business of each cell to put to work 20 of these amino<br>
     acids, which are called building blocks, to form the proteins.<br>
<br>
So where did these amino acids come from? What is the origin of amino<br>
     acids? See &quot;The Origin of Life on the Earth,&quot; by L. E. Orgel;<br>
     Scientific American, October 1994., the Stanley Miller experiment first<br>
     published in 1953 where he applied a spark to a mix of gases resembling<br>
     early conditions on Earth out of which two amino acids of the 20 were<br>
     formed. Also see info re: Murchison meteorite, which impacted with<br>
     Earth in 1969, in which 80 amino acids were found, out of which were<br>
     ample building blocks, i.e. nucleotides, for the formation of life. &quot;By<br>
     extrapolation of these results, some writers have presumed that all of<br>
     life's building could be formed with ease in Miller-type experiments<br>
     and were present in meteorites and other extraterrestrial bodies. This<br>
     is not the case.&quot; (Source: Scientific American)<br>
<br>
Amino acids make proteins. These proteins do a variety of tasks, they<br>
     are the _handymen_ of living cells. But it doesn't end there. The<br>
     handymen; that is, the proteins need enzymes, which are _expeditors_<br>
     which hasten chemical processes, making them useful for life.<br>
<br>
It is the DNA which contains the recipe for the construction of the<br>
     protein which cannot be copied or retrieved.<br>
<br>
Enter RNA, a class of molecule, like the DNA which is assembled in a<br>
     helix of nucleotide (protein) building blocks. RNA resembles DNA but it<br>
     is the molecule which edits and censors DNA code (instructions)<wbr>.<br>
<br>
DNA and RNA are in a matter of speaking cousins.<br>
<br>
There are clues that RNA appeared before proteins and DNA in the<br>
     evolution of life. There are small molecules, called _cofactors_ which<br>
     perform enzyme-catalyzed reactions and they carry an attached<br>
     nucleotide with no known function, so some scientists have speculated<br>
     that they are _molecular fossils_ - that is, they are relics descended<br>
     when RNA alone, without DNA ruled the natural biochemical world. We<br>
     don't really know for sure, therefore it is just a hypothesis (though<br>
     it is a good one) that life began with RNA alone.<br>
<br>
And what happened before RNA? There are still many questions we cannot<br>
     answer and until there are answers to these and other questions much of<br>
     it will be attributed to an intelligent designer because being<br>
     inexplicable the natural course for those who do not have an answer is<br>
     to invent one and attribute all things inexplicable to the<br>
     super-inventor of everything, to that mysterious supernatural thing<br>
     referred to as GOD. That isn't really an answer for anything but it is<br>
     the meme most humans adopt as reasonable. And it is difficult to<br>
     impossible to debate the existence of god, no matter how unreasonable<br>
     the belief in a belief is - with those committed to that belief. How<br>
     did that first self-replicating RNA arise? What made RNA? Are Did RNA<br>
     just emerge out of gray-green goo?<br>
<br>
There are opposing views (Miller experiment) and what has been found in<br>
     meteors is sufficient to produce the basic Watson-Crick building blocks<br>
     necessary for life.<br>
<br>
The Scientific American reported that analysis of &quot;several meteorites<br>
     led the scientists who conducted the work to a different conclusion:<br>
     inanimate nature has a bias toward the formation of molecules made of<br>
     fewer rather than greater numbers of carbon atoms, and thus shows no<br>
     partiality in favor of creating the building blocks of our kind of<br>
     life. (When larger carbon-containing molecules are produced, they tend<br>
     to be insoluble, hydrogen-poor substances that organic chemists call<br>
     tars.) I have observed a similar pattern in the results of many spark<br>
     discharge experiments.<wbr>&quot;<br>
<br>
&quot;Amino acids, such as those produced or found in these experiments, are<br>
     far less complex than nucleotides. Their defining features are an amino<br>
     group (a nitrogen and two hydrogens) and a carboxylic acid group (a<br>
     carbon, two oxygens and a hydrogen) both attached to the same carbon.<br>
     The simplest of the 20 used to build natural proteins contains only two<br>
     carbon atoms. Seventeen of the set contain six or fewer carbons. The<br>
     amino acids and other substances that were prominent in the Miller<br>
     experiment contained two and three carbon atoms. By contrast, no<br>
     nucleotides of any kind have been reported as products of spark<br>
     discharge experiments or in studies of meteorites, nor have the smaller<br>
     units (nucleotides) that contain a sugar and base but lack the<br>
     phosphate.&quot; (ibid)<br>
<br>
&quot;To rescue the RNA-first concept from this otherwise lethal defect, its<br>
     advocates have created a discipline called prebiotic synthesis. They<br>
     have attempted to show that RNA and its components can be prepared in<br>
     their laboratories in a sequence of carefully controlled reactions,<br>
     normally carried out in water at temperatures observed on Earth. Such a<br>
     sequence would start usually with compounds of carbon that had been<br>
     produced in spark discharge experiments or found in meteorites. The<br>
     observation of a specific organic chemical in any quantity (even as<br>
     part of a complex mixture) in one of the above sources would justify<br>
     its classification as &quot;prebiotic,&quot; a substance that supposedly had been<br>
     proved to be present on the early Earth. Once awarded this distinction,<br>
     the chemical could then be used in pure form, in any quantity, in<br>
     another prebiotic reaction. The products of such a reaction would also<br>
     be considered &quot;prebiotic&quot; and employed in the next step in the<br>
     sequence.&quot; (ibid)<br>
<br>
In any event the controversy is far from being resolved at this point<br>
     in time and any further explanation of the RNA first argument is way<br>
     above my pay grade but I wanted to at least lay out the essense of the<br>
     conflict which persists for this conundrum.<br>
<br>
I think it is unfortunate that many of those who favor an Intelligent<br>
     Design approach will use this as an example of the scientific inability<br>
     to explain life.<br>
<br>
There have been numerous other theories proposed for RNA or RNA type<br>
     substances playing a role in the origin of life on Earth. Most of these<br>
     theories vis-a-vis prebiotic Earth also rely on hypothetical<br>
     presumptions that Nucleotide Watson-Crick base pairs type replication<br>
     was used in the formation of life in prebiotic Earth. It has not been<br>
     possible to reproduce life using scientific experimentation; at least<br>
     not so that cytosine can be created, one of the four molecules<br>
     necessary for the Watson-Crick base for ATCG. Nor has Cytosine been<br>
     found in any analysis of meteorites or products of spark discharge<br>
     experimentation. It has been suggested that on the basis of evidence or<br>
     the lack thereof, it is unlikely that cytosine played a role in the<br>
     origin of life. However, theories that involve replicators that<br>
     function without the Watson-Crick pairs, or no replicator at all also<br>
     remain as viable alternatives.<br>
<br>
Hank Roth<br>
<br>
[user_nogender.<wbr>gif] Related Content<br>
     All quotes are Fair Use for educational purposes<br>
     Title 17 U.S.C. Section 107, Copyright Law<br>
<br>
Permalink: <a href="http://inyourface.info/ArT/Sci/Nucleic.shtml">http://inyourface.<wbr>info/ArT/<wbr>Sci/Nucleic.<wbr>shtml</a><br>
     Today is<br>
<br>
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<!-- End Recommendations -->



  </div>   <!-- |**|end egp html banner|**| -->

  <div style="clear:both; color: #FFF; font-size:1px;">.</div>
</div>

  <img src="http://geo.yahoo.com/serv?s=97359714/grpId=19479200/grpspId=1705083448/msgId=17502/stime=1263322584/nc1=3848642/nc2=5741391/nc3=5522131" width="1" height="1"> <br>

<div style="color: #fff; height: 0;">__,_._,___</div>
<!--~-|**|PrettyHtmlEnd|**|-~-->

</body>

<!--~-|**|PrettyHtmlStart|**|-~-->
<head>
  <style type="text/css">
  <!--
  #ygrp-mkp {
  border: 1px solid #d8d8d8;
  font-family: Arial;
  margin: 10px 0;
  padding: 0 10px;
}

#ygrp-mkp hr {
  border: 1px solid #d8d8d8;
}

#ygrp-mkp #hd {
  color: #628c2a;
  font-size: 85%;
  font-weight: 700;
  line-height: 122%;
  margin: 10px 0;
}

#ygrp-mkp #ads {
  margin-bottom: 10px;
}

#ygrp-mkp .ad {
  padding: 0 0;
}

#ygrp-mkp .ad a {
  color: #0000ff;
  text-decoration: none;
}
  #ygrp-sponsor #ygrp-lc {
  font-family: Arial;
}

#ygrp-sponsor #ygrp-lc #hd {
  margin: 10px 0px;
  font-weight: 700;
  font-size: 78%;
  line-height: 122%;
}

#ygrp-sponsor #ygrp-lc .ad {
  margin-bottom: 10px;
  padding: 0 0;
}

  a {
    color: #1e66ae;
  }

  #actions {
    font-family: Verdana;
    font-size: 11px;
    padding: 10px 0;
  }

  #activity {
    background-color: #e0ecee;
    float: left;
    font-family: Verdana;
    font-size: 10px;
    padding: 10px;
  }

  #activity span {
    font-weight: 700;
  }

  #activity span:first-child {
    text-transform: uppercase;
  }

  #activity span a {
    color: #5085b6;
    text-decoration: none;
  }

  #activity span span {
    color: #ff7900;
  }

  #activity span .underline {
    text-decoration: underline;
  }

  .attach {
    clear: both;
    display: table;
    font-family: Arial;
    font-size: 12px;
    padding: 10px 0;
    width: 400px;
  }

  .attach div a {
    text-decoration: none;
  }

  .attach img {
    border: none;
    padding-right: 5px;
  }

  .attach label {
    display: block;
    margin-bottom: 5px;
  }

  .attach label a {
    text-decoration: none;
  }
  
  blockquote {
    margin: 0 0 0 4px;
  }

  .bold {
    font-family: Arial;
    font-size: 13px;
    font-weight: 700;
  }

  .bold a {
    text-decoration: none;
  }

  dd.last p a {
    font-family: Verdana;
    font-weight: 700;
  }

  dd.last p span {
    margin-right: 10px;
    font-family: Verdana;
    font-weight: 700;
  }

  dd.last p span.yshortcuts {
    margin-right: 0;
  }

  div.attach-table div div a {
    text-decoration: none;
  }

  div.attach-table {
    width: 400px;
  }

  div.file-title a, div.file-title a:active, div.file-title a:hover, div.file-title a:visited {
    text-decoration: none;
  }

  div.photo-title a, div.photo-title a:active, div.photo-title a:hover, div.photo-title a:visited {
    text-decoration: none;
  }

  div#ygrp-mlmsg #ygrp-msg p a span.yshortcuts {
    font-family: Verdana;
    font-size: 10px;
    font-weight: normal;
  }

  .green {
    color: #628c2a;
  }

  .MsoNormal {
    margin: 0 0 0 0;
  }

  o {
    font-size: 0;
  }

  #photos div {
    float: left;
    width: 72px;
  }

  #photos div div {
    border: 1px solid #666666;
    height: 62px;
    overflow: hidden;
    width: 62px;
  }

  #photos div label {
    color: #666666;
    font-size: 10px;
    overflow: hidden;
    text-align: center;
    white-space: nowrap;
    width: 64px;
  }

  #reco-category {
    font-size: 77%;
  }

  #reco-desc {
    font-size: 77%;
  }

  .replbq {
    margin: 4px;
  }

  #ygrp-actbar div a:first-child {
   /* border-right: 0px solid #000;*/
    margin-right: 2px;
    padding-right: 5px;
  }

  #ygrp-mlmsg {
    font-size: 13px;
    font-family: Arial, helvetica,clean, sans-serif;
    *font-size: small;
    *font: x-small;
  }

  #ygrp-mlmsg table {
    font-size: inherit;
    font: 100%;
  }

  #ygrp-mlmsg select, input, textarea {
    font: 99% Arial, Helvetica, clean, sans-serif;
  }

  #ygrp-mlmsg pre, code {
    font:115% monospace;
    *font-size:100%;
  }

  #ygrp-mlmsg * {
    line-height: 1.22em;
  }

  #ygrp-mlmsg #logo {
    padding-bottom: 10px;
  }

  #ygrp-mlmsg a {
    color: #1E66AE;
  }

  #ygrp-msg p a {
    font-family: Verdana;
  }

  #ygrp-msg p#attach-count span {
    color: #1E66AE;
    font-weight: 700;
  }

  #ygrp-reco #reco-head {
    color: #ff7900;
    font-weight: 700;
  }

  #ygrp-reco {
    margin-bottom: 20px;
    padding: 0px;
  }

  #ygrp-sponsor #ov li a {
    font-size: 130%;
    text-decoration: none;
  }

  #ygrp-sponsor #ov li {
    font-size: 77%;
    list-style-type: square;
    padding: 6px 0;
  } 

  #ygrp-sponsor #ov ul {
    margin: 0;
    padding: 0 0 0 8px;
  }

  #ygrp-text {
    font-family: Georgia;
  }

  #ygrp-text p {
    margin: 0 0 1em 0;
  }

  #ygrp-text tt {
    font-size: 120%;
  }

  #ygrp-vital ul li:last-child {
    border-right: none !important; 
  } 
  -->
  </style>
</head>

<!--~-|**|PrettyHtmlEnd|**|-~-->
</html>
<!-- end group email -->


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