Re: Blast not symmetrical?

"Michael Nuhn" <[email protected]> Thu, 18 Jan 2007 17:18:04 +0100
Newsgroups gmane.science.biology.informatics.devel
Message-ID <01de01c73b1c$3b6a8c30$80baf683@nbc1>
Hello, Marty!

Thanks for your response:

> This is correct, BLAST is not symmetrical. Some assume that it is and
> make some pretty serious mistakes.

Which part of the algorithm makes Blast not symmetrical?

> Switch to Smith-Waterman and you
> will eliminate this problem.

SW of two genomes (2Mb each)? Any programs come to mind that can do that? (I
really don't know)

Thanks in advance,
Michael.