Fw: **New Drugs Could Help People Live To 150 Years

This is a post of mine on another group.  John W.



----- Forwarded Message -----
>From: John W <[email protected]>
>To: "[email protected]" <[email protected]> 
>Cc: "[email protected]" <[email protected]>; John W <[email protected]> 
>Sent: Tuesday, 12 March 2013 8:26 AM
>Subject: Re: **Chaos-Stars New Drugs Could Help People Live To 150 Years
> 
>
>Oh yes, I expect to live to be at least 150, and be still alive in 2100. But if everyone did, $ocial $ecurity in the U$A, and all other state pension and private superannuation schemes would become "toast".
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>However, resveratrol , see http://en.wikipedia.org/wiki/Resveratrol , also known as trans-3,5,4'-Trihydroxystilbene,
>3,4',5-Stilbenetriol, trans-Resveratrol, or (E)-5-(p-Hydroxystyryl)resorcinol, or (E)-5-(4-hydroxystyryl)benzene-1,3-diol, appears to only act as an anti-oxidant, being also anti-inflammatory, preventing DNA mutations and DNA strands becoming linked together by reaction with free radicals. This is only one of the two major was in which ageing occurs as the result of body cells becoming progressively unable to replenish themselves by division as they die, generally having a lifespan less than 7 years. Use of other antioxidants along with it, especially selenium (other principal ones are vitamins A, C, and E), along with it would very probably have a synergistic effect. 
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>The other main cause of permanent loss of cells is progressive shortening of the telomeres (see
>http://en.wikipedia.org/wiki/Telomere , the protective ends of each strand of DNA. These suffer shortening at each cell division, causing cell division to be slower, slower, until, after about 50 divisions, they are completely gone and cells can no longer divide; - the "Hayflick Limit", http://en.wikipedia.org/wiki/Hayflick_limit . This would put a "cap" on lifespan of about 350 years, with the maximum possible effect of anti-oxidants. 
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>This is UNLESS the telomeres are regenerated by the action of the enzyme telomerase, see 
>
>http://en.wikipedia.org/wiki/Telomerase  . However, this enzyme naturally occurs only in cancer cells (which are effectively immortal until their host dies, reproducing faster than normal cells), and reproductive cells (which are haploid, unlike all others which are diploid). It is "normally" absent in ordinary cells, but theoretically its production could somehow be "switched on" in them, resulting in cell immortality. Research is being done into how to do this and so prevent ageing, BUT without increasing the danger of cancer, e.g. by the Geron Corporation; see http://www.geron.com ,  http://en.wikipedia.org/wiki/Geron_Corporation .
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>See also: http://en.wikipedia.org/wiki/DNA_damage_theory_of_aging , http://en.wikipedia.org/wiki/Maximum_life_span , http://en.wikipedia.org/wiki/Rejuvenation_(aging) , http://en.wikipedia.org/wiki/Senescence ,
>http://en.wikipedia.org/wiki/Immortality , http://en.wikipedia.org/wiki/Centromere .
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>John W.
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>>________________________________
>> From: Julienne <[email protected]>
>>To: [email protected] 
>>Sent: Tuesday, 12 March 2013 7:00 AM
>>Subject: **Chaos-Stars New Drugs Could Help People Live To 150 Years
>> 
>>
>>  
>>DRUG BEING DEVELOPED USING COMPOUND FOUND IN RED WINE 'COULD HELP
>>HUMANS LIVE UNTIL THEY ARE 150'
>>By Lucy Crossley
>>Daily Mail
>>March 10, 2013
>>
>>http://nhne-pulse.org/new-drug-could-extend-human-life-to-150-years/
>>
>>http://www.dailymail.co.uk/health/article-2291254/New-drug-developed-using-compound-red-wine-help-humans-live-150.html
>>
>>Drugs that could combat ageing and help people to live to 150-years-old
>>may be available within five years, following landmark research.
>>
>>The new drugs are synthetic versions of resveratrol which is found in
>>red wine and is believed to have an anti-ageing effect as it boosts
>>activity of a protein called SIRT1.
>>
>>Pharmaceutical giant GlaxoSmithKline has been testing the medications on
>>patients suffering with medical conditions including cancer, diabetes
>>and heart disease.
>>
>>The work proves that a single anti-ageing enzyme in the body can be
>>targeted, with the potential to prevent age-related diseases and extend
>>lifespans.
>>
>>As each of the 117 drugs tested work on the single enzyme through a
>>common mechanism is means that a whole new class of anti-ageing drugs is
>>now viable, which could ultimately prevent cancer, Alzheimer's disease
>>and type 2 diabetes.
>>
>>Genetics professor David Sinclair, based at Harvard University, said:
>>'Ultimately, these drugs would treat one disease, but unlike drugs of
>>today, they would prevent 20 others.
>>
>>'In effect, they would slow ageing.'
>>
>>The target enzyme, SIRT1, is switched on naturally by calorie
>>restriction and exercise, but it can also be enhanced through activators.
>>
>>The most common naturally-occurring activator is resveratrol, which is
>>found in small quantities in red wine, but synthetic activators with
>>much stronger activity are already being developed.
>>
>>Although research surrounding resveratrol has been going on for a
>>decade, until now the basic science had been contested.
>>
>>Despite this, there have already been promising results in some trials
>>with implications for cancer, cardiovascular disease and cardiac
>>failure, type 2 diabetes, Alzheimer's and Parkinson's diseases, fatty
>>liver disease, cataracts, osteoporosis, muscle wasting, sleep disorders
>>and inflammatory diseases such as psoriasis, arthritis and colitis.
>>
>>Professor Sinclair said: 'In the history of pharmaceuticals, there has
>>never been a drug that tweaks an enzyme to make it run faster.'
>>
>>The technology was sold to GlaxoSmithKline in 2008.
>>
>>Four thousand synthetic activators, which are 100 times as potent as a
>>single glass of red wine, have been developed -- with the best three
>>being used in human trials.
>>
>>Writing in the journal Science, Professor Sinclair, who suggests the
>>first therapeutic to be marketed will be for diabetes, said: 'Our drugs
>>can mimic the benefits of diet and exercise, but there is no impact on
>>weight.'
>>
>>Limited trials have been carried out in people with type 2 diabetes and
>>the skin inflammatory disease, psoriasis.
>>
>>Scientists found that there were benefits to the metabolism in the first
>>group and a reduction in skin redness in the second.
>>
>>The drugs can be administered orally, or topically.
>>
>>So far, there have been no drugs developed to target ageing skin, but
>>one major skin care range has developed a creme with resveratrol in it.
>>
>>While any drug would be strictly prescribed for certain conditions,
>>Professor Sinclair suggests that one day, they could be taken orally as
>>a preventative.
>>
>>They could therefore be used in the same way as statin drugs are
>>commonly prescribed to prevent, instead of simply treating,
>>cardiovascular disease.
>>
>>In animal models, overweight mice given synthetic resveratrol were able
>>to run twice as far as slim mice and they lived 15 per cent longer.
>>
>>Professor Sinclair added: 'Now we are looking at whether there are
>>benefits for those who are already healthy.
>>
>>'Things there are also looking promising. We're finding that ageing
>>isn't the irreversible affliction that we thought it was.
>>
>>'Some of us could live to 150, but we won't get there without more
>>research.'
>>
>>.................
>>
>>RELATED LINK:
>>
>>Pulse on Aging & Anti-Aging
>>http://nhne-pulse.org/category/aging-category/
>>
>>....................
>>
>>David Sunfellow
>>Founder & President
>>NewHeavenNewEarth (NHNE)
>>[email protected]
>>Phone: (928) 239-4133
>>Fax: (815) 642-0117
>>
>>We are what we pretend to be, so we must be careful what we pretend 
>>to be. Kurt Vonnegut
>>
>>
>
>

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