What we used to talk about here Fwd: Morning Glory question

-------- Forwarded Message --------
Subject: Re: Morning Glory question
Date: Mon, 03 Sep 2012 22:46:04 -0400
From: riburr <[email protected]>
Organization: Aioe.org NNTP Server
Newsgroups: alt.drugs.psychedelics
References: <[email protected]> 
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<[email protected]>

Bobbie Sellers wrote:
> riburr wrote:
>> Bobbie Sellers wrote:
>>> riburr wrote:
>>>> At least two species of Morning glory have ancient historical usage in
>>>> the New World as a visionary plants. It's anthropological importance
>>>> was
>>>> uncovered by Richard Schultes and others, and Albert Hoffman confirmed
>>>> the presence of LSD-like alkaloids.
>>>>
>>>> Although Dr. Hoffman made his discovery of LSD using ergot fungus as
>>>> the
>>>> source, he was working with many chemical extractions and modifications
>>>> of the alkaloids from ergot, some of which must have been identical or
>>>> very similar to the alkaloids found in morning glory. Did he not notice
>>>> any mental effects from any of these alternate alkaloids until he
>>>> stumbled on the effects of LSD?
>>>
>>> No because he got the `contact´ high only from LSD, i.e.
>>> he had not changed his chemical handling procedures due to the
>>> weak reactions from the other ergot containing compounds.
>>> He touched had touched the LSD, which touching of other
>>> chemicals,had given him no reaction.
>>> And then he rode his bicycle home.
>>> When we can remember that bicycle trip anniversary
>>> we celebrate the discovery of the most active psycho-chemical
>>> ever yet discovered active in micro-gram amounts. Remember most
>>> of the psychoactive chemicals took much higher doses of hundreds
>>> of milligrams to elicit their particular reactions.
>>>
>>
>> So, if he was impressed by the psychological effects of LSD, did he not
>> become curious if some of the other, similar alkaloids might have
>> psychological effects, if only at greater dosages? I know many
>> experiments were done manipulating the LSD structure once its
>> psychological properties had been revealed. But, it seems logical that
>> some of the already known alkaloids would've have been explored first,
>> at dosages comparable to already known psychological chemicals.
>
>      He had no reaction to them under the same circumstances he
> had to LSD so perhaps he did not consider them worthy of attention.
>>
>> Also, since he, and presumably others, were looking at ergot alkaloids
>> as a treatment for postpartum bleeding, these would eventually be tested
>> in humans. Did none of the test subjects report unusual psychological
>> effects?
>
>      Well the ergot related compounds release to use were picked
> on the basis of the ability to contract blood vessels and the psycho-
> active qualities would have been negative indicators for wide use.
> Consider the circumstance of a miscarriage or normal delivery with
> bleeding and you might understand why this is so.
>      Other ergot with caffeine compounds were used for
> migraine headaches and with the complications of migraines
> no one is interested in a trip with a head full of pain.
>

Ok, did a little research.  Ergine, or lysergic acid amide (LSA or 
LA-111) had been isolated by Hoffman, and he self-administered the 
substance in 1947, and described some of the psychological effects (a 
500 microgram dose led to a tired, dreamy state, with an inability to 
maintain clear thoughts).  At the time of Hoffman's experiment ergine 
was unknown in nature.

Ergine is one of the more prevalent alkaloids in morning glory seed.  If 
Hoffman self-administered ergine, he probably did so with other ergot 
alkaloids.  The CIA also funded experiments for the acquisition, 
isolation and characterization of intoxicating substances found in a 
species of morning glory (Rivea corymbosa).  See:
http://en.wikipedia.org/wiki/Ergine#History

Interestingly, the ergot compound you mention as a treatment for 
migraine has an interesting commentary by Sasha Shulgin in TIHKAL under 
the LSD chapter (#26).

"UML-491, Methysergide, Sansert. This is the synthetic homologue of 
methergine (1-methyl) and is employed clinically as a treatment for 
migraine headaches. When the usual therapeutic dosage of two milligrams 
is scaled up by a factor of ten, there is a profound LSD-like response 
described by most subjects."



-- 
"The way she dances makes my world stand still
And she’s spinning in the sky
Every move is like a psychedelic pill
 From a doctor I can’t buy."

- Neil Young & Crazy Horse

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