Libraries and Perl64

Does Perl64 have any trouble using 32 bit libraries on a 64 bit system?

For instance, the we have 5.6, 5.7 and 5.8 Solaris systems which have a
NFS mounted location for /usr/local/lib which may contain libraries
built on any of the OS versions.  What I am seeing is that when trying
to compile certain Perl mods it complains about unreferenced symbols or
missing libraries when in fact my LD_RUN_PATH and LD_LIBRARY_PATH are
set so that those libs are where they should be...

Thanks for help!